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, Juan Berenguer Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón , Madrid , Spain Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Correspondence: Juan Berenguer, MD, PhD, Unidad de Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Doctor Esquerdo 46, 28007 Madrid, Spain (jbb4@me.com); Salvador Resino, PhD, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda- Pozuelo (Km 2,2), 28220 Majadahonda, Madrid, Spain (sresino@isciii.es). Search for other works by this author on: Oxford Academic Inmaculada Jarrín Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Centro Nacional de Epidemiología, Instituto de Salud Carlos III , Madrid , Spain Search for other works by this author on: Oxford Academic José M Bellón Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón , Madrid , Spain Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Search for other works by this author on: Oxford Academic Cristina Díez Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón , Madrid , Spain Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Search for other works by this author on: Oxford Academic María A Jiménez-Sousa Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Centro Nacional de Microbiología, Instituto de Salud Carlos III , Majadahonda , Spain Search for other works by this author on: Oxford Academic Juan C López Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón , Madrid , Spain Instituto de Investigación Sanitaria Gregorio Marañón , Madrid , Spain Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Search for other works by this author on: Oxford Academic Adriana Pinto-Martínez Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain HIV Unit and Internal Medicine, Hospital 12 de Octubre , Madrid , Spain Instituto de Investigación, Hospital 12 de Octubre , Madrid , Spain Search for other works by this author on: Oxford Academic Santiago Moreno Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Infectious Diseases, Hospital Universitario Ramón y Cajal , Madrid , Spain Instituto Ramón y Cajal de Investigación Sanitaria , Madrid , Spain Search for other works by this author on: Oxford Academic María L Montes Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain HIV Unit and Internal Medicine, Hospital Universitario la Paz , Madrid , Spain Instituto de Investigación, Hospital Universitario La Paz , Madrid , Spain Search for other works by this author on: Oxford Academic José A Iribarren Infectious Diseases, Hospital Universitario Donostia , San Sebastián , Spain Instituto de Investigación Sanitaria Biodonostia , San Sebastián , Spain Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0001-8541-8200 , Eva Orviz Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Infectious Diseases and Internal Medicine, Hospital Clínico de San Carlos , Madrid , Spain Instituto de Investigación Sanitaria, Hospital Clínico de San Carlos , Madrid , Spain Search for other works by this author on: Oxford Academic Joaquín Portilla Infectious Diseases and Internal Medicine, Hospital General Universitario de Alicante , Alicante , Spain Search for other works by this author on: Oxford Academic Francesc Villarroya Departamento de Bioquímica y Biomedicina Molecular, Universitat de Barcelona , Barcelona , Spain Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición , Madrid , Spain Search for other works by this author on: Oxford Academic Pere Domingo Infectious Diseases, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain Search for other works by this author on: Oxford Academic Salvador Resino Centro de Investigación Biomédica en Red de Enfermedades Infecciosas , Madrid , Spain Centro Nacional de Microbiología, Instituto de Salud Carlos III , Majadahonda , Spain Correspondence: Juan Berenguer, MD, PhD, Unidad de Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Doctor Esquerdo 46, 28007 Madrid, Spain (jbb4@me.com); Salvador Resino, PhD, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda- Pozuelo (Km 2,2), 28220 Majadahonda, Madrid, Spain (sresino@isciii.es). Search for other works by this author on: Oxford Academic
The Journal of Infectious Diseases, Volume 230, Issue 2, 15 August 2024, Pages 421–425, https://doi.org/10.1093/infdis/jiae168
Published:
01 April 2024
Article history
Received:
21 December 2023
Editorial decision:
27 March 2024
Accepted:
29 March 2024
Published:
01 April 2024
Corrected and typeset:
23 April 2024
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Juan Berenguer, Inmaculada Jarrín, José M Bellón, Cristina Díez, María A Jiménez-Sousa, Juan C López, Adriana Pinto-Martínez, Santiago Moreno, María L Montes, José A Iribarren, Eva Orviz, Joaquín Portilla, Francesc Villarroya, Pere Domingo, Salvador Resino, CoRIS Cohort , Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV, The Journal of Infectious Diseases, Volume 230, Issue 2, 15 August 2024, Pages 421–425, https://doi.org/10.1093/infdis/jiae168
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Abstract
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 kg and 0.98 kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.
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HIV, antiretroviral therapy, weight gain, genetics, mitochondrial DNA
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Issue Section:
Brief Report > HIV/Aids
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